prezi presentation grade 8

What is Prezi and How Can it Be Used to Teach? Tips & Tricks

Prezi is a powerful presentation system that uses lots of media types making it very versatile as a teaching tool

Prezi is a presentation tool that uses different media types to help make whatever is being shown as engaging as possible. This is specifically targeted at education, as well as business users.

The free version offers lots of functionality, but there are more features on the education-specific tiered payment options. 

Everything is made with easy-to-use guidance and templates so it can be utilized both by educators and students alike. This is a helpful way to learn design but also acts as a useful online tool for sharing with students wherever they are, in or out of the class.

So is Prezi the right tool for you?

What is Prezi?

Prezi  is a multimedia presentation tool that is based online and works across most devices with a browser window. That makes this very minimal in terms of strain on the device but also on the user, who should find everything clear to understand.

Prezi is made up of three basic sections: Prezi Video, Prezi Design, and Prezi Present. 

Prezi Video allows educators to present streamed video to the class from wherever they are. This, with Present, is more than just a video as you can add in images, graphs, documents, and more to be overlaid on the screen as you talk.

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Prezi Design is a template-based slideshow-style presentation builder. This lets you create a slideshow with rich media such as images, video, graphs, and more.

Prezi Present is a bit like a combination of the above two, letting you create video-based presentations that combine slides, PowerPoints, videos, and more.

How does Prezi work?

Prezi is easy to sign up to with just your email and name needed to start an account. You can be in the system and building your own presentation within a minute or two. You're then given all the options on a clear home page that features the sub sections mentioned above, all listed on the left menu bar.

Jump into the Prezi Design section, for example, and as you can see in the above image, you're met with an intuitive slideshow design template that you can edit to suit your needs.

Usefully, in the Present section, you can upload a PowerPoint you've already created and use that in your presentation, adding your own video as needed or editing the presentation itself. Similarly, in the Design section you can upload your own PDF and DOC files to convert and use in your presentation.

A wide range of templates is available and makes starting very easy, and can be a helpful way to make sure the learning curve isn't too steep for younger students using this tool.

What are the best Prezi features?

Prezi is graphically very inviting as everything is spaced out without too much clutter or information, making it very intuitive even if it's your first time with this or any presentation tool.

Videos are easy to record immediately from within the website, allowing teachers and students to upload directly from their smartphones or laptops. The ability to layer more information in these videos, effectively combining a slideshow presentation and a video presentation, is a super appealing feature here.

The library feature offers lots of different projects, including pre-recorded videos, that can be used freely. There are more options in the paid versions, and you can be pestered to upgrade as you use the system, however generally, the free versions can be enough for teaching.

How much does Prezi cost?

Prezi is free to use the Basic plan, which is limited to five projects, however, there are also paid options specifically for educators.

There is a Plus version for educators, priced at $5 per month , which gets you unlimited projects, importing of PowerPoints, PDF export, video download, the desktop app, and offline access.

The Pro version, at $10 per month , has all the above plus analytics, training, and support.

The EDU Teams plan is available for scaling up, and is offered on a quotation basis.

Prezi best tips and tricks

Turn in Have students turn in projects using Prezi to teach them how to design and layout work in a more engaging way, which for example, could be useful in future jobs.

Be timeless Create a presentation lesson and save it so you can use it again the following year, or share with other teachers that may find it helpful.

Flip the class Build a lesson presentation and have students work through it before coming to class, then use what they've learned to hold a debate in the room to see how well the content has been understood.

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Luke Edwards is a freelance writer and editor with more than two decades of experience covering tech, science, and health. He writes for many publications covering health tech, software and apps, digital teaching tools, VPNs, TV, audio, smart home, antivirus, broadband, smartphones, cars and much more.

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Need a good presentation topic? Here are hundreds of them.

Get your team on prezi – watch this on demand video.

Anete Ezera November 04, 2022

If you’re looking for good topics for presentations, you’ve landed on the right page. In this article, you’ll find plenty of good presentation topics, tips on choosing the most suitable presentation topic for you, and essential design elements to make your presentation a success. 

Many factors go into an excellent presentation. You need to have confident body language and engage your audience to hold their attention. You also need eye-catching visual aids like images, data visualizations, GIFs, and others (all of which you can find in Prezi ), not to mention a great opening to grab attention and a strong closing line to stay memorable. However, the most essential aspect of your presentation is the topic. It’s the core of your presentation, so it has to be strong, insightful, attention-grabbing, and appealing to yourself and your audience in order to evolve into a successful presentation everyone will love. 

How to choose a good presentation topic

There are millions of topics you could create a presentation on, but what defines a good presentation topic? If you’re struggling to either come up with a good topic for a presentation or you can’t decide between multiple ones, here are a few questions you should ask yourself before choosing a topic. 

What’s the goal of your presentation? 

When you’re choosing a presentation topic, consider the meaning behind it. Ask yourself what the purpose of talking about this topic is, and what you want to say about it. Whatever topic you choose to present, the conclusion needs to provide a takeaway or lesson you want to communicate to your audience. A meaningful goal will make your presentation more memorable.  

Are you interested in the topic?

If you’re not interested in the presentation topic, others won’t be curious either. Interest, enthusiasm, and passion enrich your presentation and are noticeable when presenting. Interest shines through and inspires others to find the topic as fascinating as you do. Think about the last time you saw someone sharing something they were passionate about – their excitement drew people in to pay closer attention to what they were saying. 

When choosing a topic, you need to find it or a particular angle of it interesting for yourself. For example, perhaps you’re not a pop music enthusiast, but you’re passionate about studying cultural phenomena. In this case, you can talk about pop music’s influence on early 2000s youth culture. 

Will your audience find this topic relatable? 

While you have to find the topic you’re presenting interesting, you also have to think about your audience. When choosing a subject, consider your audience’s background in terms of demographics, interests, culture, and knowledge level about the topic. Think about what others will find fascinating and relevant, so they’re not bored or confused during your presentation.

Do you have prior experience or knowledge about this topic?

Personal experiences are always great to share in a presentation, providing your unique perspective for anyone listening. While you can easily prepare your presentation based on a quick Google search, it won’t make the same lasting impact on your audience. Choose a presentation topic you have some prior knowledge about, or have an interesting opinion you can share with others. It’ll make your presentation more engaging and memorable.

Ideas for good presentation topics

It’s not easy to come up with a good presentation topic from scratch. It’s much easier to get inspired from other good presentation topics to build your topic on. Whether you’re looking for presentation ideas for work, about me presentation ideas, unique or easy presentation topics, you’ll find them all here.

Without further ado, here are some good presentation topics to choose from or get inspired by.

Presentation topics about social media

• The role of social media in portraying gender stereotypes
• How social media impacts our body image
• How social media shaped Gen Z 
• The most significant differences between the Facebook and TikTok generations
• The negative effects of social media
• The positive impacts of social media 
• The effects of social media on behavior 
• How social media impacts our physical (or mental) health
• How social media has shaped our understanding of mass media
• Should we teach about social media in schools?
• The rise of social media influencers
• How AR Instagram filters impact our self-image
• How to go viral on social media?
• The origins of social media echo chambers
• Social media as a news outlet

Author: Ish Verduzco

Presentation topics about movies

• How movies influence our understanding of good and evil
• Beauty standards represented in movies
• How female characters are depicted in Hollywood movies
• How horror movies and global fears have developed through time
• The adverse effects of romance movies
• How movies have changed our understanding of the Western culture
• Charlie Chaplin and the silent movie era
• The globalization of culture: Hollywood vs. Bollywood
• The psychology behind the music in films
• The ethics of using animals in movies
• Social media’s influence on the film industry
• The history of filmmaking
• The role of color in movies
• The cultural impact of romance movies
• How are gender stereotypes depicted in Hollywood movies?

Author: Cinto Marti

Presentation topics about music

• The impact of pop music on beauty standards
• Should digital music be free for everyone?
• The psychology behind the music in advertisements 
• The effectiveness of sound therapy
• Can music inspire criminal behavior?
• The psychological effects of metal music
• The origins of K-pop
• How does music influence our understanding of the world?
• Can music help in the learning process?
• The positive effects of classical music
• The history of hip hop
• Why is music education essential in schools?
• The psychological benefits of playing piano
• Can anyone become a famous musician?
• The role of music in fashion

Author: Prezi Editorial

Presentation topics about health

• The link between food and mental health
• Inequality in the healthcare system
• Myths about healthy practices
• Simple practices that help you stay healthy
• Health education in schools: Should it change?  
• Toxic positivity and mental health
• The impact of superfoods on our health
• The psychology behind unhealthy eating habits
• Sex education in schools: Why should we have it?
• How to trick yourself into getting better: The placebo effect
• How to strengthen your immune system
• How to tell if someone is depressed
• The health benefits of regular exercise
• The impact of junk food on mental health
• Stress-caused diseases

Author: Prezi Education Team

Presentation topics about human psychology

• What is social depression?
• What triggers panic attacks?
• The impact of testosterone on aggressive behavior
• How to overcome social anxiety
• Differences in the functioning of the brain of a child and adult
• The impact of violent video games on children’s brain development
• How does the use of social media influence our attention span?
• How to overcome childhood trauma
• The influence of marijuana on the human brain
• How does behavioral therapy work
• The psychology behind fame
• The causes of personality disorders
• The differences in brain functioning between men and women
• What happens in therapy sessions?
• The psychology of substance abuse 

Presentation topics about self-development

• The impact of exercise on productivity
• How to deal with stress
• How to deal with procrastination
• The positive effects of meditation
• Why new–year’s resolutions don’t work
• How to overcome bad habits
• The impact of negative thoughts
• The negative effects of self-criticism
• The role of creativity in self-development
• Benefits of journaling
• How to learn something fast
• How to be mindful
• The importance of curiosity 
• How to become more self-aware
• Why it’s essential to spend time with yourself

Author: Nir Eyal

Presentation topics about education

• What are the advantages and disadvantages of online education?
• The positive effects of a gap year
• Should university education be free?
• Inequality in education access
• How language learning benefits brain development
• Emerging gender issues in education
• The importance of socialization in school
• School bullying and student development
• The benefits of reading 
• Is the education system broken?
• What you don’t learn in college
• The link between education and brain development
• The history of schools
• The gender gap in STEM
• The connection between equality in education and economic growth

Presentation topics about culture

• Is graffiti a form of art or street vandalism? 
• Cultural diversity in the workplace
• The impact of culture on gender roles
• The issue with orientalism
• Are humans the only species that has culture?
• How do different cultures view death? 
• The ethical issues of pop culture
• The impact of culture on personal development
• Sexism in different cultures
• The impact of globalization on local cultures
• The viral spread of the #metoo movement
• The history of subcultures
• The problem with romanticizing toxic relationships in movies
• 90s pop-culture influence on fashion trends
• The evolution of cultural psychology 

Author: Devin Banerjee

Presentation ideas for work

• What it’s like to be a digital nomad?
• How to deal with workplace conflicts
• The secret to a productive day
• How to set achievable goals
• The importance of diversity in a workplace
• The positive effects of creative thinking at work
• How to give constructive feedback
• The characteristics of a valuable team member
• Inequality and the glass ceiling
• Racial discrimination in the workplace
• Work habits of different cultures
• How is work perceived in various countries?
• Technological development and the future of work
• The importance of a healthy work/life balance
• The rise of health problems in office work

Author: Charles Huang

Presentation topics about hybrid work

• The positive effects of hybrid work on work/life balance
• Is hybrid work the future work model? 
• How to stay connected in a hybrid work model
• The challenges of hybrid work nobody talks about
• How to stay productive when working from home
• The social effects of hybrid work
• The economic impacts of hybrid work
• Case study: Hybrid work model in [company]
• What causes Zoom fatigue?
• The problem with online meetings
• Is hybrid work better than remote work?
• How to develop a close relationship with colleagues in a hybrid work model
• What kind of company culture is best for a hybrid work model?
• Is hybrid work sustainable?
• Cybersecurity consideration for hybrid working

Author: Barbie Brewer

Presentation topics about public speaking

• The importance of body language in public speeches
• How to appear confident when you’re not
• How to become a better orator
• The use of eye contact in public speaking
• Breathing exercises that will calm you down before public speaking
• The benefits of public speaking
• Ways to improve public speaking skills
• How to leave a great first impression on stage
• How to engage your audience during a public speech
• How to best structure your public speech
• How to end your presentation speech
• Can anyone learn to be good at public speaking?
• How to prepare for a public speech
• What not to do right before a public speech
• How to address a controversial topic in a public speech  

Author: Prezi Team

Presentation topics about entrepreneurship and leadership

• The main principles of a good leader
• The impact of leadership skills on professional performance
• The mistake every entrepreneur makes
• How to successfully lead a cross-cultural team
• How to celebrate inclusivity in a diverse team
• What are the common personality traits of a successful entrepreneur?
• The impact of entrepreneurship on the global economy
• The characteristics of a leader
• The most common challenges of entrepreneurship
• Can anyone learn to become a successful leader? 
• What affects new venture growth?
• The psychology of leadership
• What is crowdsourcing? 
• The benefits of being an entrepreneur
• Common mistakes leaders make

Author: Jill Sinclair

Presentation topics about technology

• The rise of technological development
• Is technology addictive?
• Should we use drones for military and non-military purposes?
• The sustainability of electric cars
• What are deepfakes?
• Limitations of AI machines
• The future of programming
• Ethical issues of AI
• The future of AR in business
• How VR can be used in the medical field

Author: David Vandegrift

Sales presentation topics

• How to make a cold email intro
• What is sales enablement?
• How to build better relationships with customers
• The best way to improve pipeline management
• Coaching via verbal and written role-play
• How to plan cold calls
• What’s a deal-breaker for most customers? 
• All about personalized coaching
• How to manage objections
• How to close more deals
• How to keep your prospects engaged
• Effective sales communication strategies
• How to conduct a competitor analysis
• The most valuable sales skills
• What soft skills do you need to become a successful sales rep?

Author: Cindy McGovern

Easy presentation topics

• Benefits of daily exercise and how to incorporate it into your routine
• Simple and nutritious meal recipes
• Tips for improving time management and productivity
• The importance of recycling
• The history of a local landmark or festival
• Ways to reduce stress
• Exploring different types of renewable energy sources and their impact on the environment
• The basics of budgeting and saving money for future goals
• The benefits of social media for professional use
• Tips for overcoming stage fright
• How to start a meditation practice
• The impact of technology on modern society
• The basics of personal finance
• The health benefits of a plant-based diet
• The history of Earth Day

Good how to presentation topics

• How to create a successful social media marketing strategy
• How to give a persuasive presentation
• How to create effective and engaging content for your blog
• How to discover your strengths and weaknesses
• How to use project management tools to increase productivity
• How to make the most out of boring meetings
• How to build a personal brand
• How to conduct effective market research
• How to use data analytics to improve decision-making
• How to improve your decision-making process
• How to write a winning proposal
• How to create a visually stunning presentation
• How to manage stressful situations at work
• How to make friends as an adult
• How to network at work events

About me presentation ideas

• My journey to becoming who I am today
• My passion for [insert topic or activity]
• My career aspirations and goals
• My travels and adventures around the world
• My hobbies and interests outside of work/school
• My role models and influences
• My strengths and weaknesses
• My favorite books, movies, and TV shows
• My proudest achievements and accomplishments
• My favorite childhood memories
• My family and friends
• My education and academic background
• My volunteer and community service experience
• My personality traits and values
• My vision for the future and how I plan to achieve it

Author: Adam Grant

Student presentation ideas

• The history and evolution of video games
• The history and cultural impact of tattoos
• The impact of social media on body image and self-esteem
• The effects of globalization on local cultures and economies
• The role of education in promoting social justice and equity
• The ethical implications of autonomous weapons in warfare
• The impact of mass media on society and culture
• The causes and effects of deforestation on biodiversity and climate change
• The history and cultural significance of dance in different parts of the world
• The psychology of addiction and recovery
• The impact of the gig economy on labor rights and job security
• The history and impact of feminism on gender equality
• The benefits and drawbacks of renewable energy sources
• The impact of colonialism on indigenous cultures and identities
• The role of technology in promoting global connectivity and intercultural understanding

Author: Edward Quinn

Informative presentation topics

• The science of sleep: How to get a restful night and improve your wellbeing
• A journey through the history of the internet
• Exploring the potential of AI in our world
• Climate change: Understanding the challenge, seeking solutions for a sustainable future
• How new technologies are shaping the future of food
• Understanding the psychology of money for financial success
• The power of a story: How storytelling captures hearts and minds
• Mastering the art of negotiation in every interaction
• The science of happiness: Unlocking the secrets to a more fulfilling life
• The power of mindfulness for a more present and peaceful YOU
• Understanding cybersecurity threats and protecting yourself online
• Exploring the potential of virtual reality for a more immersive future

Author: Andrew Davis

How to create a good presentation 

If you know what you want to present on, it’s time to create an impactful presentation that grabs everyone’s attention. Presentation design plays a crucial role in how your presentation is received and remembered. To stand out and leave a memorable impact on your audience, create a Prezi presentation. Instead of a linear, slide-based presentation, offer an engaging and dynamic storytelling experience to your audience. Breathe life into your presentation with motion, zoom, and spatial relationships. When creating your presentation, consider the following three essential elements: 

Visuals play a significant part in presentation design. They evoke emotions, make a memorable impact, and give more context to the story. Not to mention, 65% of people are visual learners , so visual aids are helpful when explaining a complex topic. 

In your presentation, include different types of visuals, such as images, videos, GIFs, and stickers, all of which you can find in Prezi’s content library. When selecting your visuals, consider what’s relevant and brings additional value to the story. Only add what’s meaningful and necessary. A video or image at the right place and time will enrich the viewing experience and make your presentation more memorable. 

The layout of your presentation is the structure of your story. It’ll help you introduce the topic, intrigue your audience, and unfold the layers of your topic one by one until you disclose your main arguments and summarize the presentation. A good presentation layout has a hierarchical, chronological, or logical flow that leads the viewer from start to finish. 

If you’re creating a Prezi presentation, you can create a dynamic storytelling experience by experimenting with your layout. Instead of going from slide to slide, you can zoom in and out of topics and experiment with different shapes, animations, and effects that draw the viewer into your story world. Here’s an example of a Prezi presentation with a great storytelling layout:

Author: Lydia Antonatos

Data visualizations can elevate your presentation from being a good one to a great one. By providing data behind your arguments, you’ll appear more trustworthy and confident in your audience’s eyes. 

Add charts, graphs, interactive maps, and more to your presentations with Prezi Design. You can choose from a wide selection of charts and maps to illustrate your data. With interactive elements, you’ll be able to engage your audience and make a memorable impact. 

Engaging visuals, a well-structured layout, and relevant data visualizations will provide a great starting base to create a memorable presentation. Discover other tips and tricks that make your presentation effective and capture people’s attention. 

Prezi AI for presentation success

If you already have a clear presentation style in mind or plenty of time for creation, fantastic! But what if you only have a day or less or you don’t know where to start? Enter Prezi AI . It’s your assistant for streamlining the presentation creation process. Here’s how Prezi AI leverages the power of artificial intelligence to turn you into a presentation pro:

Effortless design from scratch

Ditch the blank page anxiety with the AI presentation maker . Simply provide a title or outline, and Prezi AI will generate a visually appealing draft presentation in seconds. It’s like having a built-in design assistant ready to brainstorm with you.

Smarter text, stronger impact

Prezi’s AI text-editing tool helps you perfect your message in seconds. It analyzes your content, suggesting improvements for readability and conciseness.

From bullet points to animations

Let’s face it, static bullet points can put even the most dynamic presenter to sleep. Prezi’s AI animated slides maker transforms your text into captivating visual stories. Choose from formats like flowcharts, animated lists, or zoom reveals to keep your audience engaged.

Perfect for busy presenters

We all know the struggle – a million tasks on your plate, and a looming presentation deadline. Prezi AI can help you save valuable time! With AI assistance, you can generate presentations faster, focus on refining your content, and present with the confidence that comes from knowing your presentation looks polished and professional.

Design help

Don’t worry if you don’t have an eye for design. Prezi AI provides the tools and guidance to create presentations that impress visually.

With Prezi AI, crafting presentations is easy, allowing you to focus on delivering your message with impact and leaving your audience engaged and inspired. Explore what’s possible with Prezi A I today!

Learn more on how to turn your presentation topic into a stunning presentation with AI:

Final thoughts on selecting good presentation topics

Choosing a topic for a presentation isn’t easy. When selecting a topic, think about the goal of your presentation, your interests, and knowledge about the topic, and whether or not your audience will find it relevant and interesting for them. Also, get inspired by other topics that’ll help you figure out what you want to talk about. Lastly, when creating your presentation, consider the impact of visuals, layout, and data visualizations. To simplify the creation process, try Prezi AI or follow the step-by-step process of making a presentation with helpful tips and resources.

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8 Parts of Speech Prezi

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This is a digital download Prezi presentation that will provide you and your students terms, definitions, and examples of the 8 English parts of speech. Presentation is embedded with youtube videos, many pictures, and humor. It was originally designed for 7th grade students.

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• Published: 12 August 2024

Micropapillary breast carcinoma in comparison with invasive duct carcinoma. Does it have an aggressive clinical presentation and an unfavorable prognosis?

• Yasmine Hany Abdel Moamen Elzohery 1 , 5 ,
• Amira H. Radwan 2 , 5 ,
• Sherihan W. Y. Gareer 2 , 5 ,
• Mona M. Mamdouh 3 , 5 ,
• Inas Moaz 4 , 5 ,
• Abdelrahman Mohammad Khalifa 5 ,
• Osama Abdel Mohen 5 ,
• Mohamed Fathy Abdelfattah Abdelrahman Elithy 5   nAff6 &
• Mahmoud Hassaan 5   nAff7  

BMC Cancer volume  24 , Article number:  992 ( 2024 ) Cite this article

168 Accesses

Metrics details

Invasive micropapillary carcinoma (IMPC) was first proposed as an entity by Fisher et al. In the 2003 World Health Organization (WHO) guidelines for histologic classification of the breast tumors. IMPC was recognized as a distinct, rare histological subtype of breast cancer.

IMPC is emerging as a surgical and oncological challenge due to its tendency to manifest as a palpable mass, larger in size and higher in grade than IDC with more rate of lymphovascular invasion (LVI) and lymph node (LN) involvement, which changes the surgical and adjuvant management plans to more aggressive, with comparative prognosis still being a point of ongoing debate.

Aim of the study

In this study, we compared the clinicopathological characteristics, survival and surgical management of breast cancer patients having invasive micropapillary carcinoma pathological subtype in comparison to those having invasive duct carcinoma.

This is a comparative study on female patients presented to Baheya center for early detection and treatment of breast cancer, in the period from 2015 to 2022 diagnosed with breast cancer of IMPC subtype in one group compared with another group of invasive duct carcinoma. we analyzed 138 cases of IMPC and 500 cases of IDC.

The incidence of LVI in the IMPC group was 88.3% in comparison to 47.0% in the IDC group (p < 0.001). IMPC had a higher incidence of lymph node involvement than the IDC group (68.8% and 56% respectively). IMPC had a lower rate of breast conserving surgery (26% vs.37.8%) compared with IDC.

The survival analysis indicated that IMPC patients had no significant difference in overall survival compared with IDC patients and no differences were noted in locoregional recurrence rate and distant metastasis rate comparing IMPCs with IDCs.

The results from our PSM analysis suggested that there was no statistically significant difference in prognosis between IMPC and IDC patients after matching them with similar clinical characteristics. However, IMPC was found to be more aggressive, had larger tumor size, greater lymph node metastasis rate and an advanced tumor stage.

Peer Review reports

Introduction

Breast cancer is the most common cancer in women. In the 2012 World Health Organization (WHO) classification of breast cancer. Breast Cancer is classified into up to 21 different histological types depending on cell growth, morphology and architecture patterns [ 1 ]. The invasive carcinoma of no special type (IBC-NST), which is known as invasive ductal carcinoma (IDC), is the most frequently occurring histological type, which constitutes around 75% of invasive breast carcinoma [ 2 ].

Invasive micropapillary carcinoma (IMPC) was first proposed as an entity by Fisher et al. in 1980 [ 3 ] and first described as the term “invasive micropapillary carcinoma” by Siriaunkgul et al. [ 4 ] in 1993.

In the 2003 World Health Organization (WHO) guidelines for histologic classification of the breast tumors [ 5 ]. IMPC was recognized as a distinct, rare histological subtype of breast cancer. While micropapillary histological architecture is present in 2–8% of breast carcinomas, pure micropapillary carcinoma is uncommon and accounts for 0.9–2% of all breast cancers [ 6 ].

IMPC exhibits more distinct morphologic architecture than the IDC, characterized by pseudopapillary and tubuloalveolar arrangements of tumor cell clusters in clear empty sponge-like spaces that resemble extensive lymphatic invasion [ 7 ]. The neoplastic cell exhibits an “inside-out” pattern, known as the reverse polarity pattern [ 2 ].

Most studies demonstrate that the radiological findings of IMPC are irregular-shaped masses with an angular or spiculated margin on ultrasound, mammography and MRI with heterogeneous enhancement and washout kinetics on MRI [ 8 ].

IMPC had tendency to manifest as a palpable mass, larger in size and higher in grade than IDC with more rate of lymphovascular invasion (LVI) and lymph node (LN) involvement, which changes the surgical and adjuvant management plans to more aggressive, with comparative prognosis still being a point of ongoing debate [ 9 ].

In this study, we compared the clinicopathological characteristics, survival and surgical management of breast cancer patients having invasive micropapillary carcinoma pathological subtype in comparison to those having invasive ductal carcinoma.

Patient and method

This is a comparative study on female patients presented to Baheya center for early detection and treatment of breast cancer, in the period from 2015 to 2022 diagnosed with breast cancer of IMPC subtype in one group compared with another group of invasive duct carcinoma.

This retrospective study analyzed 138 cases of IMPC and 500 cases of IDC. Informed consent was obtained from all patients. Ethical approval is obtained from Baheya center for early detection and treatment of breast cancer and National research center ethics committee. Baheya IRB protocol number:202305150022.

The following clinical-pathological features were analyzed for each case: patient age at diagnosis, clinical presentation, laterality, imaging findings, histopathological examination, treatment plan with either primary surgical intervention or other treatment protocol according to tumor stage and biological subtypes.

A breast pathologist evaluated the tumor size, type, grade, lymphovascular invasion, estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) receptor and the axillary lymph node involvement.

According to the ASCO/CAP guideline update, 2019: Samples with 1% to 100% of tumor nuclei positive for ER or progesterone receptor (PgR) are interpreted as positive. If ER (not PgR), 1% to 10% of tumor cell nuclei are immunoreactive, the sample are reported as ER Low Positive. There are limited data on the overall benefit of endocrine therapies for patients with low level (1%-10%) ER expression, but they currently suggest possible benefit, so patients are considered eligible for endocrine treatment. A sample is considered negative for ER or PgR if < 1% or 0% of tumor cell nuclei are immunoreactive [ 10 ]. An Allred score between 0 and 8. This scoring system looks at what percentage of cells test positive for hormone receptors, along with how well the receptors show up after staining, called intensity: proportion of cells staining (0, no staining; 1, < 1%; 2, between 1 and 10%; 3, between 11 and 33%; 4, between 34 and 66% and 5, between 67%–100% of the cells staining). Intensity of positive tumor cells (0, none; 1, weak, 2, intermediate; and 3, strong) [ 11 ].

HER2 Test Guideline IHC Recommendations, 2018. IHC 0: as defined by no staining observed or membrane staining that is incomplete and is faint/barely perceptible and within <  = 10% of the invasive tumor cells. IHC 1 + : as defined by incomplete membrane staining that is faint/barely perceptible and within > 10% of the invasive tumor cells. IHC 2 + : The revised definition of IHC 2 + (equivocal) is weak to moderate complete membrane staining observed in > 10% of tumor cells. IHC 3 + : based on circumferential membrane staining that is complete, intense in > 10% of tumor cells. [ 12 ].

ASCO–CAP HER2 SISH Test Guideline Recommendations,2018 Twenty nuclei (each containing red (Chr17) and black (HER2) signals) should be enumerated. The final results for the HER2 status are reported based on the ratio formed by dividing the sum of HER2 signals for all 20 nuclei divided by the sum of Chromosome 17 signals for all 20 nuclei. The amplification status is defined as Amplified if the HER2/Chromosome 17 ratio > / = 2.0 and the average Her2 gene copy number is > / = 4.0. It is non-Amplified if the HER2/Chromosome 17 ratio < 2.0 with the Her2 gene copy number is < 4.0. If the HER2/Chr17 ratio is < 2 and the Her2 gene copy number is between 4.0 and 6.0, or, HER2/Chr17 ratio is > / = 2 and the Her2 gene copy number is < 4, or HER2/Chr17 ratio is < 2 and the Her2 gene copy number is > / = 6.0, an additional work should be done. [ 12 ].

Follow-up duration was calculated from the date of diagnosis to the date of the last follow-up. Patients still alive at the last follow-up censored or to the date of occurrence of any event or death.

Disease-free survival was defined as the duration (months) from the initial diagnosis of breast cancer to first any type of recurrence (invasive ipsilateral breast tumor recurrence, local invasive recurrence, regional invasive recurrence, invasive contra lateral breast cancer, distant metastasis.

Overall survival (OS) is defined as the time from diagnosis of breast cancer to death from any cause.

Data were statistically analyzed using an IBM-compatible personal computer with Statistical Package for the Social Sciences (SPSS) version 23. Quantitative data were expressed as mean, standard deviation (SD) and range (minimum–maximum). Qualitative data were expressed as Number (N) and percentage (%), while A P value of < 0.05 was statistically significant. For comparison of unmatched data, chi-square tests were used for categorical variables and t-tests or Mann–Whitney tests for continuous variables.

In this study, we analyzed 138 cases of IMPC which presented to our center in the period from 2015 to 2022.We included a total number of 500 cases of IDC as controls with a ratio of controls to cases 4:1.

Propensity score matching (PSM) is a method for filtrating experimental and control cases of similar characteristics, which are called the matching variables, from existing data to make them comparable in a retrospective analysis. PSM reduce the effect of selection bias. So, the comparison of outcomes between two groups can be fair.

The variables for propensity score matching were selected as follows: age (years), tumour size (cm), nodal status, HR status and HER2 status.

To diminish the effects of baseline differences and potential confounds in clinical characteristics and patients across histology subtypes for outcome differences (disease-free survival and overall survival), PSM method was applied with each micropapillary patient matched to one IDC patient who showed similar baseline characteristics in terms of: menopausal status, comorbidities, multiplicity, histologic grade, tumor size, stage, nodal status, ER /PR status. Differences in prognosis were assessed by Kaplan–Meier analysis.

Most of the patients were postmenopausal, the mean age of patients in IMPC group was 57.36 ± 11.321 years while the mean age of the IDC group was 56.63 ± 9.719 years ( p  = 0.45) (Table 1 ).

The most common presentation of IMPC on breast mammography was an irregular shaped mass with a non-circumscribed spiculated margin. while, the most common sonographic finding of IMPC was hypoechoic mass with irregular shapes and spiculated margins. Associated microcalcifications were found in 49 patients (35.5%) of IMPC group. Figs. ( 1 , 2 ): Radiological characteristics of IMPC.

A , B 37-years-old female patient presented with Left breast UOQ extensive fine pleomorphic and amorphous calcifications of segmental distribution, with UOQ multiple indistinct irregular masses. C ultrasound showed left breast UOQ multiple irregular hypoechoic masses with calcific echogenic foci, the largest is seen at 1 o’clock measuring 13 × 15mm. Intraductal echogenic lesions are noted

A , B , C 40-years-old female patient presented with left UOQ extensive pleomorphic microcalcifications of segmental distribution reaching the areola, with multiple well-circumscribed small obscured masses. D , E complementary Ultrasound showed left 2 o’clock multiple ill-defined and well-defined hypoechoic masses (BIRADS 5)

All patients underwent axillary sonography where 77 patients (55.8%) of the IMPC group exhibited pathological lymph nodes and 18 patients (13%) had indeterminate lymph nodes demonstrating preserved hila and associated with either a symmetrical increase of their cortical thickness reaching 3mm or with a focal increase in the cortical thickness.

Multiple lesions were detected in 30% of IMPC patients in comparison to 7% of IDC patients. Intra-ductal extension with nipple involvement was found in 44 patients (31.9%) of the IMPC group (Table 2 ).

MRI was done for 5 cases (3.6%), while CESM was performed for 18 cases (13%) of the IMPC group, the commonest presentation of IMPC in contrast study was irregular shaped enhanced mass in 21 patients and non-mass enhancement was found in 5 patients. Figs. ( 3 , 4 ).

Further imaging modalities. A , B , C 60-years-old female patient had right breast irregular hypoechoic solid mass by ultrasound (BIRADS 5). D , E CESM showed a right breast irregular heterogeneously enhancing solid mass

Role of CESM in diagnosis of IMPC patients. A , B 42-years-old patient presented with a left LIQ irregular spiculated mass with suspicious microcalcifications, other similar lesions were seen anterior and posterior at the same line. C Ultrasound showed a heterogeneously hypoechoic irregular mass with a spiculated outline with multiple similar satellite lesions were seen anterior and posterior to the main lesions

The average tumor size in the IMPC and IDC groups was 3.37 ± 2.04 cm and 2.72 ± 1.39 cm, respectively ( P  < 0.001).

The percentage of tumors larger than 5cm, was reported 9.5% in IMPC and 7.4% in IDC.

The pure form of IMPC was the most common type and found in 90 cases (65%) and 47 cases (34%) were mixed type where IDC was the commonest associated type.

There are 6 cases in the IMPC group diagnosed as invasive mucinous carcinoma on biopsy, then in the specimen was mixed invasive micropapillary, IBC-NST and invasive mucinous carcinoma.

On core biopsy, 28 cases were diagnosed as IMPC with focal IDC component, but in corresponding specimens 10 cases were only approved to be mixed invasive micropapillary and invasive duct carcinoma, while others diagnosed as pure invasive micropapillary carcinoma without IDC component.

On the other hand, 48 of our cases were diagnosed as IDC on core biopsy, but in the final specimen examination, 17 of these cases were diagnosed as pure invasive micropapillary carcinoma without invasive ductal component.

The explanation of controversy in proper histologic subtyping of carcinoma on core biopsy and the definite subtype on the corresponding specimen was that the ductal component which only represented in the biopsy is a very minor component of the tumor or the limited sampling, tissue fragmentation and architecture distortion in core biopsy may cause diagnostic pitfalls as regard precise subtyping of the tumor.

The incidence of LVI in the IMPC group was 88.3% in comparison to 47.0% in the IDC group ( p  < 0.001).

IMPC had a higher incidence of lymph node involvement than the IDC group (68.8% and 56% respectively) with N3 stage reported in 12.4% of IMPC patients.

IMPC had a higher nuclear grade than the IDC group (25.1% and 15.2% respectively).

The percentage of ER-positive patients was 97.8% in the IMPC group and 87.6% in the IDC group ( p  < 0.001), while PR-positive cases were 98.6% in the IMPC group and 88.8% in the IDC group ( p  < 0.001). HER2 status was positive in 4.3% of IMPCs and 8% of IDCs ( p  = 0.23) (Table 3 ) (Figs. 5 ,  6 ).

A case of invasive micropapillary carcinoma. A case of invasive micropapillary carcinoma, grade II. A Tissue core biopsy, × 100, B MRM specimen × 100 with Positive metastatic L. nodes 2/15, C ER is positive in > 90% of tumor cells, × 100, D PR is positive in > 90% of tumor cells, × 400, E HER2/neu is negative, × 400 and F) Ki-67 labelling index is high, × 200. This case was considered as luminal type pure invasive micropapillary carcinoma. (100 micron 20__ 50 micron 40)

A case of invasive duct carcinoma. A case of invasive duct carcinoma, grade II. A Tissue core biopsy, × 100, B MRM specimen, × 200 with negative L. nodes 0/16, C ER is positive in > 90% of tumor cells, × 200, D PR is positive in > 90% of tumor cells, × 100, E HER2/neu is negative, × 400. This case was considered as luminal type pure invasive duct carcinoma

Regarding definitive surgical management, IMPC had a lower rate of breast conserving surgery (26% vs.37.8%) compared with IDC. While, 49.3% of IMPC patients underwent modified radical mastectomy in comparison to 46% of the IDC patients. Such high incidence of mastectomy was due to the advanced stage at presentation, presence of multiple lesions and presence of intra-ductal extension with nipple involvement.

The incidence of re-surgery in the IMPC group was only in 3 cases, two of them underwent completion mastectomy after the initial conservative breast surgery and axillary clearance. While one patient underwent wider margin excision as positive margin for an invasive residual disease was found.

Two patients in the IMPC group had distant metastasis at the initial diagnosis, they had multiple metastatic lesions and received systemic treatment but one of them underwent palliative mastectomy.

Systemic chemotherapy was administered to 107 patients (77.5%) in the IMPC group and to 207 patients (41%) in the IDC group. Hormonal therapy was administered to all IMPC patients and 76% patients in the IDC group (Table 4 ).

The overall median follow-up duration was 21 months (range 6 – 88 months) with mean follow up duration = 29.8months.

Among the 138 IMPC patients, local recurrence developed in 3 cases, they developed a recurrence at 6,18 and 48 months postoperative. Distant metastasis developed in 5 patients in the form of bone, lung, hepatic and mediastinal lymph node metastasis.

The survival analysis indicated that IMPC patients had no significant difference in overall survival compared with IDC patients and no differences were noted in locoregional recurrence rate comparing IMPCs with IDCs (2.2% and 0.4% respectively). P value for local recurrence = 0.12 (yates corrected chi square).

Distant metastasis rate comparing IMPCs with IDCs was (3.7% and 5.4% respectively). P value for distant metastasis = 0.53 (Table 5 ).

Comparison of OS between IDC and micropapillary cases (Matched by propensity score matching -PSM).

Case Processing Summary

Overall Comparisons

• Test of equality of survival distributions for the different levels type

Disease free survival

• Test of equality of survival distributions for the different levels of type

IMPC is a highly invasive type of breast cancer. Hashmi A.A. et al. [ 13 ] found that the incidence of IMPC is very low accounting for 0.76–3.8% of breast carcinomas.

Shi WB et al.; [ 7 ] in a study comparing 188 IMPC cases and 1,289 invasive ductal carcinoma (IDC) cases from China showed that IMPC can occur either alone or mixed with other histological types, such as ductal carcinoma in situ, mucinous carcinoma and IDC. Furthermore, the majority of patients had mixed IMPC.

Fakhry et al. [ 14 ] reported that 64.7% of IMPC patients were pure type. In our study, we found that the pure form of IMPC was the commonest type and presented in 90 patients (65%) and 47 cases (34%) were mixed type which was similar to that reported by Nassar et al. [ 15 ], and Guo et al. [ 16 ] in their studies.

In our study, the commonest finding of IMPC on breast mammography was an irregular shaped mass with a non-circumscribed spiculated margin. While, the commonest sonographic finding of IMPC was hypoechoic mass with irregular shapes and spiculated margins.

These findings were similar to the results demonstrated by Jones et al., [ 17 ] which found that the commonest morphologic finding of IMPC was an irregular high-density lesion (50% of patients) with spiculated margin (42% of patients). However, Günhan-Bilgen et al. [ 18 ] reported that an ovoid or round lesion was found in 53.8% of patients.

Alsharif et al., [ 19 ] reported that the commonest sonographic finding of IMPC was hypoechoic masse (39/41, 95%) with irregular shape (30/41, 73.2%) and angular or spiculated margin (26/41, 63.4%).

In our study, MRI was done for 5 cases (3.6%), while CESM was performed for 18 cases (13%) of the IMPC group, the commonest presentation of IMPC in contrast study was irregular shaped enhanced lesion in 21 cases and non-mass enhancement was presented in 5 cases.

Nangogn et al. [ 20 ] and yoon et al. [ 8 ] recorded that the commonest finding of IMPCs in MRI was spiculated irregular mass with early rapid initial heterogenous enhancement, indicating that the MRI findings correlated with the invasiveness of IMPC.

Fakhry et al. [ 14 ] conducted a study on 68 cases, out of which 17 cases underwent CEM. In all of these cases, the masses showed pathological enhancement, which was either in the form of mass enhancement (12/17 patients, 70.6%) or non-mass enhancement (4/17 patients, 23.5%). The majority of the enhanced masses were irregular in shape (11/12 patients, 91.7%).

All patients underwent axillary sonography and 77 patients (55.8%) of the IMPC group exhibited pathological lymph nodes; this percentage was similar to that recorded by Nangong et al. [ 20 ] which was 54.8% and lower than that recorded by Jones et al. [ 17 ] but higher than that of Günhan et al. [ 18 ] which were 67% and 38% respectively.

Günhan et al. [ 18 ] reported microcalcification in about 66.7% of the cases. In our study, associated microcalcifications were found in 49 patients (35.5%) of the IMPC group. Yun et al. [ 21 ] and Adrada et al. [ 22 ] showed a fine pleomorphic appearance (66.7% and 68%).

Hao et al. [ 23 ] compared the rate of tumors larger than 5cm, reporting 3% in IDC and 4.3% in IMPC. In our study, the rate of tumors larger than 5cm, was reported 7.4% in the IDC patients and 9.5% in the IMPC patients.

Yu et al., et al. [ 24 ] documented in a study comparing 72 cases of IMPC and 144 cases of IDC of the breast that IMPC had a higher nuclear grade than IDC (52.8% vs. 37.5% respectively). In our study, IMPC had a higher nuclear grade than the IDC group (25.1% and 15.2% respectively).

Verras GI et al.; [ 9 ] demonstrated that IMPC was an aggressive breast cancer subtype with a great tendency to lymphovascular invasion and lymph node metastasis. In our study, the incidence of LVI in the IMPC patients was 88.3% in comparison to 47.0% in the IDC patients ( p  < 0.001). Tang et al., [ 25 ] also reported that lymphovascular involvement was more common among the IIMPC group than IDC group, with a percentage of 14.7% compared to only 0.1% in the IDC group.

Also, Shi et al. [ 7 ] reported that LVI was detected in 74.5% of cases. Furthermore, the frequency of LVI was found to be greater in IMPC cases when compared to IDC cases. Jones et al., [ 17 ] recorded angiolymphatic invasion in 69% of cases.

Hashmi et al. [ 13 ] reported in his comparative study that nodal involvement was present in 49.5% of IDC patients and N3 stage was only 15.6% in IDC patients compared to 33% in IMPC patients. In our study, the percentage of lymph node involvement of IMPC and IDC patients were 68.8% and 56% respectively with N3 stage reported in 12.4% of IMPC patients.

Guan et al. [ 26 ], Lewis et al., [ 27 ], Pettinato et al., [ 28 ] and De La Cruz et al., [ 29 ] recorded a higher percentage of lymph node metastasis in IMPC patients, reaching 90%, 92.9%,55.2% and 60.9% respectively.

The management of IMPC remains controversial, particularly among breast surgeons. Modified radical mastectomy was the preferred surgical procedure for the majority of IMPC case reports, as found in a study conducted by Yu et al., [ 24 ] where 99% of IMPC cases underwent modified radical mastectomy. Fakhry et al. [ 14 ] reported that 76.5% of the patients underwent modified radical mastectomy. In our study, 49.3% of IMPC patients received modified radical mastectomy.

IMPC patients were also prone to accept BCS rather than mastectomy in the previous series conducted by Lewis GD,et al. [ 27 ] and Vingiani, A. et al. [ 30 ]. However, the precise prognosis value of BCS for patients with IMPC remained unknowable. In our study, IMPC had a lower rate of breast conserving surgery (26% vs.37.8%) compared with IDC.

IMPC was characterized by a high incidence of ER and PR positivity. Our study recorded a high percentage of ER (97.8%) and PR (98.6%) expression. Our findings are similar to those found by Walsh et al., [ 31 ] who reported ER and PR expression of 90% and 70%, respectively. Zekioglu et al. [ 32 ] demonstrated a rate of ER and PR expression of 68% and 61%respectively.

In this study, we reported a relatively lower percentage of HER-2 positivity (4.3%). Also, Nangong et al. [ 20 ] showed HER 2 overexpression in 26.4% of cases.

However, Cui et al. [ 33 ] reported a much higher incidence of HER 2 positivity and Perron et al., [ 34 ] reported that 65% of IMPCs were HER-2 positive.

Chen, A et al. [ 35 ] reported that that the percentage of radiation therapy for IMPC patients was similar to those seen in IDC patients and demonstrates a similar benefit of radiation treatment in both groups. In our study,77.5% patients received radiotherapy in IMPC group in compared to 59.4% patients in IDC group.

Shi et al. [ 7 ] found that patients with IMPC had worse recurrence-free survival (RFS) and overall survival (OS) rates as compared to those with IDC. However, because IMPC is relatively rare, most studies had reported on small sample sizes with limited follow-ups.

Yu et al., [ 24 ] conducted a comparison between IMPC and IDC patients, and the results showed that the IMPC group had a greater tendency for LRR compared to the IDC group ( P  = 0.03), but the distant metastasis rate ( P  = 0.52) and OS rate ( P  = 0.67) of the IMPC showed no statistical differences from the IDC group.

Nevertheless, several recent studies documented that IMPC had better or similar prognosis in comparison to IDC.

Hao et al. [ 23 ] and Vingiani et al. [ 30 ] documented that there was no statistically significant difference in OS and disease-free survival between IMPC patients and IDC patients which was similar to our results. locoregional recurrence rate comparing IMPCs with IDCs was (2.2% and 0.4% respectively). P value for local recurrence = 0.12 (yates corrected chi square). Distant metastasis rate comparing IMPCs with IDCs was (3.7% and 5.4% respectively). P value for distant metastasis = 0.53.

Chen H et al. [ 36 ], compared the overall survival in patient groups with similar nodal involvement and found that IMPC group had better breast cancer–specific survival and overall survival than IDC group.

Availability of data and materials

No datasets were generated or analysed during the current study.

Abbreviations

Invasive micropapillary carcinoma

Invasive duct carcinoma

Modified radical mastectomy

Conserving breast surgery

Estrogen receptor

Progesterone receptor

Lymphovascular invasion

Contrast enhanced spectral mammography

Overall survival

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Author information

Mohamed Fathy Abdelfattah Abdelrahman Elithy

Present address: Department of Surgical Oncology, Faculty of Medicine, Al Azhar University, Cairo, Egypt

Mahmoud Hassaan

Present address: Departement of Surgical Oncology, National Cancer Institute, Cairo University, Giza, Egypt

Authors and Affiliations

Department of General Surgery, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Yasmine Hany Abdel Moamen Elzohery

Department of Radiodiagnosis, NCI, Cairo University, Giza, Egypt

Amira H. Radwan & Sherihan W. Y. Gareer

Department of Pathology, National Cancer Institute, Cairo University, Giza, Egypt

Mona M. Mamdouh

Department of Epidemiology and Preventive Medicine, National Liver Institute, Menoufia, Egypt

Baheya Center for Early Detection and Treatment of Breast Cancer, Giza, Egypt

Yasmine Hany Abdel Moamen Elzohery, Amira H. Radwan, Sherihan W. Y. Gareer, Mona M. Mamdouh, Inas Moaz, Abdelrahman Mohammad Khalifa, Osama Abdel Mohen, Mohamed Fathy Abdelfattah Abdelrahman Elithy & Mahmoud Hassaan

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Mohamed fathy participated in the sequence alignment and Yasmine hany drafted the manuscript. Mahmoud Hassan participated in the design of the study. Inas Moaz and Abdelrahman Mohammad performed the statistical analysis. Amira H. Radwan and Sherihan WY Gareer conceived the study. Mona M Mamdouh and Osama abdel Mohen participated in its design and coordination and helped to draft the manuscript. All authors read and approved the final manuscript.

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Correspondence to Yasmine Hany Abdel Moamen Elzohery .

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Elzohery, Y.H.A.M., Radwan, A.H., Gareer, S.W.Y. et al. Micropapillary breast carcinoma in comparison with invasive duct carcinoma. Does it have an aggressive clinical presentation and an unfavorable prognosis?. BMC Cancer 24 , 992 (2024). https://doi.org/10.1186/s12885-024-12673-0

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Received : 05 April 2024

Accepted : 23 July 2024

Published : 12 August 2024

DOI : https://doi.org/10.1186/s12885-024-12673-0

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